Functional interaction of Junctophilin 2 with small- conductance Ca²⁺ -activated potassium channel subtype 2(SK2) in mouse cardiac myocytes.

ABSTRACT:

Aim

Junctophilins (JPs), a protein family of the junctional membrane complex, maintain the close conjunction between cell surface and intracellular membranes in striate muscle cells mediating the crosstalk between extracellular Ca²⁺ entry and intracellular Ca²⁺ release. The small-conductance Ca²⁺ -activated K⁺ channels are activated by the intracellular calcium and play an essential role in the cardiac action potential profile. Molecular mechanisms of regulation of the SK channels are still uncertain. Here, we sought to determine whether there is a functional interaction of junctophilin type 2 (JP2) with the SK channels and whether JP2 gene silencing might modulate the function of SK channels in cardiac myocytes.

Methods

Associatio

SUBMITTER: Fan HK 

PROVIDER: S-EPMC6084295 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature