Transcriptome profiling of anti-mullerian hormone treated preantral/small antral mouse ovary follicles.

ABSTRACT: The predisposition for the initiation of folliculogenesis in mammals including humans is programmed to start at fetal life and continues until reproductive capacity. The follicles grow from a pool of primordial follicles which retain the major functions in the entire reproductive life of a female. Anti-müllerian hormone (AMH), a glycoprotein belonging to the transforming growth factor-beta family, has an inhibitory effect on ovarian follicle development. The key regulatory target genes in primordial follicle development are of paramount importance in reproductive biology of female. A systems biology method was used to find regulatory genes performing critical role in primordial follicle development. A complete in-depth bioinformatics analysis was performed to investigate the changes in tra

SUBMITTER: Ur Rehman Z 

PROVIDER: S-EPMC6084392 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature