Abdominal fat depots, insulin resistance, and incident diabetes mellitus in women with and without HIV infection.

ABSTRACT:

Objective

The aim of this study was to determine the associations between visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) mass with homeostatic model assessment-insulin resistance (HOMA-IR) and incidence of diabetes mellitus in women with and without HIV infection.

Design

Cross-sectional design for associations between abdominal fat and HOMA-IR; longitudinal design for associations between abdominal fat and incident diabetes.

Methods

We assessed associations between dual X-ray absorptiometry scan-derived VAT and SAT with HOMA-IR in a subsample from the Women's Interagency HIV Study (n = 226 with and n = 100 without HIV) using linear regression. We evaluated associations of VAT, SAT and HOMA-IR with incident diabetes mellitus using Cox pro

SUBMITTER: Glesby MJ 

PROVIDER: S-EPMC6084460 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature