Anisotropic biodegradable lipid coated particles for spatially dynamic protein presentation.

ABSTRACT: There has been growing interest in the use of particles coated with lipids for applications ranging from drug delivery, gene delivery, and diagnostic imaging to immunoengineering. To date, almost all particles with lipid coatings have been spherical despite emerging evidence that non-spherical shapes can provide important advantages including reduced non-specific elimination and increased target-specific binding. We combine control of core particle geometry with control of particle surface functionality by developing anisotropic, biodegradable ellipsoidal particles with lipid coatings. We demonstrate that these lipid coated ellipsoidal particles maintain advantageous properties of lipid polymer hybrid particles, such as the ability for modular protein conjugation to the particle surface us

SUBMITTER: Meyer RA 

PROVIDER: S-EPMC6084478 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature