Best practices for the design, laboratory analysis, and reporting of trials involving fatty acids.

ABSTRACT: Fatty acids are among the most studied nutrients in human metabolism and health. Endogenous fatty acid status influences health and disease via multiple mechanisms at all stages of the life cycle. Despite widespread interest, attempts to summarize the results of multiple studies addressing similar fatty acid-related outcomes via meta-analyses and systematic reviews have been disappointing, largely because of heterogeneity in study design, sampling, and laboratory and data analyses. Our purpose is to recommend best practices for fatty acid clinical nutrition and medical studies. Key issues in study design include judicious choice of sampled endogenous pools for fatty acid analysis, considering relevant physiologic state, duration of intervention and/or observation, consideration of specific

SUBMITTER: Brenna JT 

PROVIDER: S-EPMC6084616 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature