Genetic Basis of Chronotype in Humans: Insights From Three Landmark GWAS.

ABSTRACT:

Study objectives

Chronotype, or diurnal preference, refers to behavioral manifestations of the endogenous circadian system that governs preferred timing of sleep and wake. As variations in circadian timing and system perturbations are linked to disease development, the fundamental biology of chronotype has received attention for its role in the regulation and dysregulation of sleep and related illnesses. Family studies indicate that chronotype is a heritable trait, thus directing attention toward its genetic basis. Although discoveries from molecular studies of candidate genes have shed light onto its genetic architecture, the contribution of genetic variation to chronotype has remained unclear with few related variants identified. In the advent of large-scale genome-wide associati

SUBMITTER: Kalmbach DA 

PROVIDER: S-EPMC6084759 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature