Ontology highlight
ABSTRACT:
SUBMITTER: Zeng H
PROVIDER: S-EPMC6084788 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Cancer cell 20180701 1
Loss of the CDKN2A tumor suppressor is associated with melanoma metastasis, but the mechanisms connecting the phenomena are unknown. Using CRISPR-Cas9 to engineer a cellular model of melanoma initiation from primary human melanocytes, we discovered that a lineage-restricted transcription factor, BRN2, is downstream of CDKN2A and directly regulated by E2F1. In a cohort of melanocytic tumors that capture distinct progression stages, we observed that CDKN2A loss coincides with both the onset of inv ...[more]