Dynamic changes in human-gut microbiome in relation to a placebo-controlled anthelminthic trial in Indonesia.

ABSTRACT:

Background

Microbiome studies suggest the presence of an interaction between the human gut microbiome and soil-transmitted helminth. Upon deworming, a complex interaction between the anthelminthic drug, helminths and microbiome composition might occur. To dissect this, we analyse the changes that take place in the gut bacteria profiles in samples from a double blind placebo controlled trial conducted in an area endemic for soil transmitted helminths in Indonesia.

Methods

Either placebo or albendazole were given every three months for a period of one and a half years. Helminth infection was assessed before and at 3 months after the last treatment round. In 150 subjects, the bacteria were profiled using the 454 pyrosequencing. Statistical analysis was performed cross-sectional

SUBMITTER: Martin I 

PROVIDER: S-EPMC6084808 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature