Beyond the RfD: Broad Application of a Probabilistic Approach to Improve Chemical Dose-Response Assessments for Noncancer Effects.

ABSTRACT:

Background

The National Academies recommended risk assessments redefine the traditional noncancer Reference Dose (RfD) as a probabilistically derived risk-specific dose, a framework for which was recently developed by the World Health Organization (WHO).

Objectives

Our aim was to assess the feasibility and implications of replacing traditional RfDs with probabilistic estimates of the human dose associated with an effect magnitude M and population incidence I (HD_MI).

Methods

We created a comprehensive, curated database of RfDs derived from animal data and developed a standardized, automated, web-accessible probabilistic dose-response workflow implementing the WHO framework.

Results

We identified 1,464 RfDs and associated endpoints, representing 608 ch

SUBMITTER: Chiu WA 

PROVIDER: S-EPMC6084844 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature