Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure.

ABSTRACT:

Background

Modern societies are exposed to vast numbers of potentially hazardous chemicals. Despite demonstrated linkages between chemical exposure and severe health effects, there are limited, often conflicting, data on how adverse health effects of exposure differ across individuals.

Objectives

We tested the hypothesis that population variability in response to certain chemicals could elucidate a role for gene-environment interactions (GxE) in differential susceptibility.

Methods

High-throughput screening (HTS) data on thousands of chemicals in genetically heterogeneous zebrafish were leveraged to identify a candidate chemical (Abamectin) with response patterns indicative of population susceptibility differences. We tested the prediction by generating genome-wide se

SUBMITTER: Balik-Meisner M 

PROVIDER: S-EPMC6084885 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature