Remote tissue conditioning is neuroprotective against MPTP insult in mice.

ABSTRACT: Current treatments for Parkinson's disease (PD) are primarily symptomatic, leaving a need for treatments that mitigate disease progression. One emerging neuroprotective strategy is remote tissue conditioning, in which mild stress in a peripheral tissue (e.g. a limb) induces protection of life-critical organs such as the brain. We evaluated the potential of two remote tissue conditioning interventions - mild ischemia and photobiomodulation - in protecting the brain against the parkinsonian neurotoxin MPTP. Further, we sought to determine whether combining these two interventions provided any added benefit. Male C57BL/6 mice (n = 10/group) were pre-conditioned with either ischemia of the leg (4 × 5 min cycles of ischemia/reperfusion), or irradiation of the dorsum with 670 nm light (50 mW/cm<

SUBMITTER: Kim B 

PROVIDER: S-EPMC6084900 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature