Optimization of the standard genetic code according to three codon positions using an evolutionary algorithm.

ABSTRACT: Many biological systems are typically examined from the point of view of adaptation to certain conditions or requirements. One such system is the standard genetic code (SGC), which generally minimizes the cost of amino acid replacements resulting from mutations or mistranslations. However, no full consensus has been reached on the factors that caused the evolution of this feature. One of the hypotheses suggests that code optimality was directly selected as an advantage to preserve information about encoded proteins. An important feature that should be considered when studying the SGC is the different roles of the three codon positions. Therefore, we investigated the robustness of this code regarding the cost of amino acid replacements resulting from substitutions in these positions separat

SUBMITTER: Blazej P 

PROVIDER: S-EPMC6084934 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature