Controlling T2 blurring in 3D RARE arterial spin labeling acquisition through optimal combination of variable flip angles and k-space filtering.

ABSTRACT: PURPOSE:To improve the SNR efficiency and reduce the T2 blurring of 3D rapid acquisition with relaxation enhancement stack-of-spiral arterial spin labeling imaging by using variable refocusing flip angles and k-space filtering. METHODS:An algorithm for determining the optimal combination of variable flip angles and filtering correction is proposed. The flip angles are designed using extended phase graph physical simulations in an analytical and global optimization framework, with an optional constraint on deposited power. Optimal designs for correcting to Hann and Fermi window functions were compared with conventional constant amplitude or variable flip angle only designs on 6 volunteers. RESULTS:With the Fermi window correction, the proposed optimal designs provided 39.8 and 27.3% higher

SUBMITTER: Zhao L 

PROVIDER: S-EPMC6085152 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature