Patterns of efavirenz use as first-line antiretroviral therapy in the United States: 1999-2015.

ABSTRACT:

Background

Efavirenz has been a mainstay of antiretroviral therapy (ART) for over 15 years in the US. Its association with neuropsychiatric side effects may influence clinical prescribing and management.

Methods

We included HIV-infected adults enrolled in care at seven sites across the US, who initiated combination ART between 1999 and 2015. We examined the proportion initiating and continuing on efavirenz, overall and by mental health status. Log binomial and Cox models were used to estimate associations between mental health, clinical and sociodemographic characteristics and initiating or switching from efavirenz as first-line ART.

Results

Of the 8,230 participants included, 3,710 (45%) initiated efavirenz. In multivariable analyses, prior mono- or dual-ART, ART ini

SUBMITTER: Bengtson AM 

PROVIDER: S-EPMC6085156 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature