Modeling the Metabolic State of Mycobacterium tuberculosis Upon Infection.

ABSTRACT: Genome-scale metabolic models of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, have been envisioned as a platform for drug discovery. By systematically probing the networks that underpin such models, the reactions that are essential for Mtb are identified. A majority of these reactions are catalyzed by enzymes and thus represent candidate drug targets to fight an Mtb infection. Nevertheless, this is complicated by the limited knowledge on the environment that Mtb encounters during infection. Modeling the behavior of the bacteria during infection requires knowledge of the so-called biomass reaction that represents bacterial biomass composition. This composition varies in different environments or bacterial growth phases. Accurate modeling of the metabolic sta

SUBMITTER: Rienksma RA 

PROVIDER: S-EPMC6085482 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature