Fatty Acid Metabolism is Associated With Disease Severity After H7N9 Infection.

ABSTRACT:

Background

Human infections with the H7N9 virus could lead to lung damage and even multiple organ failure, which is closely associated with a high mortality rate. However, the metabolic basis of such systemic alterations remains unknown.

Methods

This study included hospitalized patients (n = 4) with laboratory-confirmed H7N9 infection, healthy controls (n = 9), and two disease control groups comprising patients with pneumonia (n = 9) and patients with pneumonia who received steroid treatment (n = 10). One H7N9-infected patient underwent lung biopsy for histopathological analysis and expression analysis of genes associated with lung homeostasis. H7N9-induced systemic alterations were investigated using metabolomic analysis of sera collected from the four patients by using ult

SUBMITTER: Sun X 

PROVIDER: S-EPMC6085509 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature