Evaluation of GWAS-Identified Genetic Variants for Gastric Cancer Survival.

ABSTRACT:

Backgrounds

Genome-wide association studies (GWASs) have identified several gastric cancer (GC) susceptibility loci in Asians, but their effects on disease outcome are still unknown. This study aimed to investigate whether these GWAS-identified genetic variants could serve as robust prognostic biomarkers for GC.

Methods

A multistage clinical cohort, including a total of 2432 GC patients in the Chinese population, was used to identify the association between GWAS-identified risk variants and overall survival of GC. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed by Cox regression analysis, and the log-rank P was calculated by the log-rank test with the Kaplan-Meier method.

Results

We found that rs2274223 A>G in PLCE1 was associated with increased G

SUBMITTER: Gu D 

PROVIDER: S-EPMC6085567 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature