Thyroid hormones and breast cancer association according to menopausal status and body mass index.

ABSTRACT:

Background

Thyroxine (T4) has been positively associated with tumor cell proliferation, while the effect of triiodothyronine (T3) on cell proliferation has not been well-established because it differs according to the type of cell line used. In Mexico, it has been reported that 14.5% of adult women have some type of thyroid dysfunction and abnormalities in thyroid function tests have been observed in a variety of non-thyroidal illnesses, including breast cancer (BC). These abnormalities might change with body mass index (BMI) because thyroid hormones are involved in the regulation of various metabolic pathways and probably by menopausal status because obesity has been negatively associated with BC in premenopausal women and has been positively associated with BC in postmenopausal w

SUBMITTER: Ortega-Olvera C 

PROVIDER: S-EPMC6085630 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature