Adipose tissue-derived extracellular fraction characterization: biological and clinical considerations in regenerative medicine.

ABSTRACT:

Background

Adipose tissue-derived stem cells are considered to be a promising source in the field of cell therapy and regenerative medicine. In addition to direct cell replacement using adipose tissue or purified stem cells, intercellular molecule exchange by the adipose tissue complex, a vast array of bioactive secretory factors, demonstrated beneficial effects by reducing tissue damage and stimulation of endogenous repair. However, for therapeutic purposes, the use of secretome derivatives, such as full conditioned media or purified exosomes generated in vitro, may present considerable disadvantages for cell manufacturing, storage, product safety, and their potential as a ready-to-go therapeutic product.

Methods

In this study, the effect of a liquid fraction of lipoaspirat

SUBMITTER: Bellei B 

PROVIDER: S-EPMC6085647 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature