Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasis.

ABSTRACT:

Background

Psoriasis is a chronic inflammatory autoimmune skin disorder. Several studies suggested psoriasis to be a complex multifactorial disease, but the exact triggering factor is yet to be determined. Evidences suggest that in addition to genetic factors, epigenetic reprogramming is also involved in psoriasis development. Major histopathological features, like increased proliferation and abnormal differentiation of keratinocytes, and immune cell infiltrations are characteristic marks of psoriatic skin lesions. Following therapy, histopathological features as well as aberrant DNA methylation reversed to normal levels. To understand the role of DNA methylation in regulating these crucial histopathologic features, we investigated the genome-wide DNA methylation profile of psorias

SUBMITTER: Chandra A 

PROVIDER: S-EPMC6085681 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature