Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer.

ABSTRACT:

Background

The close temporal association between onset of some connective tissue diseases and cancer suggests a paraneoplastic association. Adult patients with scleroderma with anti-RNA polymerase III autoantibodies and adult patients with dermatomyositis with anti-transcriptional intermediary factor 1 (anti-TIF1) or anti-nuclear matrix protein 2 (anti-NXP2) autoantibodies have a significantly increased risk of developing cancer. Autoantibodies may serve as biomarkers for early detection of cancer and also could be relevant for prediction of responses to immune therapies. We aimed to test whether myositis and scleroderma specific or associated autoantibodies are detectable in individuals with lung cancer.

Methods

Serum from 60 Caucasian patients with lung cancer (30 with sm

SUBMITTER: Betteridge ZE 

PROVIDER: S-EPMC6085683 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature