Long-term exposure to insulin and volumetric mammographic density: observational and genetic associations in the Karma study.

ABSTRACT:

Background

Long-term insulin exposure has been implicated in breast cancer etiology, but epidemiological evidence remains inconclusive. The aims of this study were to investigate the association of insulin therapy with mammographic density (MD) as an intermediate phenotype for breast cancer and to assess associations with long-term elevated circulating insulin levels using a genetic score comprising 18 insulin-associated variants.

Methods

We used data from the KARolinska MAmmography (Karma) project, a Swedish mammography screening cohort. Insulin-treated patients with type 1 (T1D, n = 122) and type 2 (T2D, n = 237) diabetes were identified through linkage with the Prescribed Drug Register and age-matched to 1771 women without diabetes. We assessed associations with treatment

SUBMITTER: Borgquist S 

PROVIDER: S-EPMC6085687 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature