Fatty acid oxidation is associated with proliferation and prognosis in breast and other cancers.

ABSTRACT:

Background

Altered cellular metabolism is a hallmark of cancer but the association between utilisation of particular metabolic pathways in tumours and patient outcome is poorly understood. We sought to investigate the association between fatty acid metabolism and outcome in breast and other cancers.

Methods

Cox regression analysis and Gene Set Enrichment Analysis (GSEA) of a gene expression dataset from primary breast tumours with well annotated clinical and survival information was used to identify genesets associated with outcome. A geneset representing fatty acid oxidation (FAO) was then examined in other datasets. A doxycycline-inducible breast cancer cell line model overexpressing the rate-limiting enzyme in FAO, carnitine palmitoyl transferase 1A (CPT1A) was generated

SUBMITTER: Aiderus A 

PROVIDER: S-EPMC6085695 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature