Counteracting roles of MHCI and CD8⁺ T cells in the peripheral and central nervous system of ALS SOD1^G93A mice.

ABSTRACT:

Background

The major histocompatibility complex I (MHCI) is a key molecule for the interaction of mononucleated cells with CD8⁺T lymphocytes. We previously showed that MHCI is upregulated in the spinal cord microglia and motor axons of transgenic SOD1^G93A mice.

Methods

To assess the role of MHCI in the disease, we examined transgenic SOD1^G93A mice crossbred with β2 microglobulin-deficient mice, which express little if any MHCI on the cell surface and are defective for CD8⁺ T cells.

Results

The lack of MHCI and CD8⁺ T cells in the sciatic nerve affects the motor axon stability, anticipating the muscle atrophy and the disease onset. In contrast, MHCI depletion in resident microglia and the lack of CD8⁺ T

SUBMITTER: Nardo G 

PROVIDER: S-EPMC6085701 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature