High mammographic density in women is associated with protumor inflammation.

ABSTRACT:

Background

Epidemiological studies have consistently shown that increased mammographic density (MD) is a strong risk factor for breast cancer. We previously observed an elevated number of vimentin⁺/CD45⁺ leukocytes in high MD (HMD) epithelium. In the present study, we aimed to investigate the subtypes of immune cell infiltrates in HMD and low MD (LMD) breast tissue.

Methods

Fifty-four women undergoing prophylactic mastectomy at Peter MacCallum Cancer Centre or St. Vincent's Hospital were enrolled. Upon completion of mastectomy, HMD and LMD areas were resected under radiological guidance in collaboration with BreastScreen Victoria and were subsequently fixed, processed, and sectioned. Fifteen paired HMD and LMD specimens were further selected according t

SUBMITTER: Huo CW 

PROVIDER: S-EPMC6085707 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature