Autism throughout genetics: Perusal of the implication of ion channels.

ABSTRACT:

Background

Autism spectrum disorder (ASD) comprises a group of neurodevelopmental psychiatric disorders characterized by deficits in social interactions, interpersonal communication, repetitive and stereotyped behaviors and may be associated with intellectual disabilities. The description of ASD as a synaptopathology highlights the importance of the synapse and the implication of ion channels in the etiology of these disorders.

Methods

A narrative and critical review of the relevant papers from 1982 to 2017 known by the authors was conducted.

Results

Genome-wide linkages, association studies, and genetic analyses of patients with ASD have led to the identification of several candidate genes and mutations linked to ASD. Many of the candidate genes encode for proteins i

SUBMITTER: Daghsni M 

PROVIDER: S-EPMC6085908 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature