Genome-Wide Changes in Protein Translation Efficiency Are Associated with Autism.

ABSTRACT: We previously proposed that changes in the efficiency of protein translation are associated with autism spectrum disorders (ASDs). This hypothesis connects environmental factors and genetic factors because each can alter translation efficiency. For genetic factors, we previously tested our hypothesis using a small set of ASD-associated genes, a small set of ASD-associated variants, and a statistic to quantify by how much a single nucleotide variant (SNV) in a protein coding region changes translation speed. In this study, we confirm and extend our hypothesis using a published set of 1,800 autism quartets (parents, one affected child and one unaffected child) and genome-wide variants. Then, we extend the test statistic to combine translation efficiency with other possibly relevant variables

SUBMITTER: Rogozin IB 

PROVIDER: S-EPMC6086092 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature