CTLA4 tagging polymorphisms and risk of colorectal cancer: a case-control study involving 2,306 subjects.

ABSTRACT:

Background

CTLA4 is a candidate gene which has been implicated in the development of colorectal cancer (CRC).

Patients and methods

To determine the important role of CTLA-4 polymorphisms on risk of CRC, we genotyped four CTLA-4 tagging polymorphisms and calculated crude/adjusted ORs with their 95% CIs. We recruited 1,003 sporadic CRC cases and 1,303 controls.

Results

The findings suggested that CTLA-4 rs231775 G>A polymorphism increased the risk of CRC (homozygote model: adjusted OR=1.40, 95% CI=1.05-1.87, P=0.022; dominant model: adjusted OR=1.19, 95% CI=1.00-1.41, P=0.047; and recessive model: adjusted OR=1.38, 95% CI=1.05-1.82, P=0.021). In a stratified analysis by site of tumor, this association was also found in colon can

SUBMITTER: Zou C 

PROVIDER: S-EPMC6086103 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature