Coinfection with Enteric Pathogens in East African Children with Acute Gastroenteritis-Associations and Interpretations.

ABSTRACT: Enteric coinfections among children in low-income countries are very common, but it is not well known if specific pathogen combinations are associated or have clinical importance. In this analysis, feces samples from children in Rwanda and Zanzibar less than 5 years of age, with (N = 994) or without (N = 324) acute diarrhea, were analyzed by real-time polymerase chain reaction targeting a wide range of pathogens. Associations were investigated by comparing co-detection and mono-detection frequencies for all pairwise pathogen combinations. More than one pathogen was detected in 840 samples (65%). A negative association (coinfections being less common than expected from probability) was observed for rotavirus in combination with Shigella, Campylobacter, or norovirus genogroup II, but only in

SUBMITTER: Andersson M 

PROVIDER: S-EPMC6086148 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature