Congenital Chagas Disease in the United States: Cost Savings through Maternal Screening.

ABSTRACT: Chagas disease, caused by Trypanosoma cruzi, is transmitted by insect vectors through transfusions, transplants, insect feces in food, and from mother to child during gestation. Congenital infection could perpetuate Chagas disease indefinitely, even in countries without vector transmission. An estimated 30% of infected persons will develop lifelong, potentially fatal, cardiac or digestive complications. Treatment of infants with benznidazole is highly efficacious in eliminating infection. This work evaluates the costs of maternal screening and infant testing and treatment of Chagas disease in the United States. We constructed a decision-analytic model to find the lower cost option, comparing costs of testing and treatment, as needed, for mothers and infants with the lifetime societal costs

SUBMITTER: Stillwaggon E 

PROVIDER: S-EPMC6086189 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature