Promoting Similarity of Sparsity Structures in Integrative Analysis with Penalization.

ABSTRACT: For data with high-dimensional covariates but small sample sizes, the analysis of single datasets often generates unsatisfactory results. The integrative analysis of multiple independent datasets provides an effective way of pooling information and outperforms single-dataset and several alternative multi-datasets methods. Under many scenarios, multiple datasets are expected to share common important covariates, that is, the corresponding models have similarity in their sparsity structures. However, the existing methods do not have a mechanism to promote the similarity in sparsity structures in integrative analysis. In this study, we consider penalized variable selection and estimation in integrative analysis. We develop an L₀-penalty based method, which explicitly promote

SUBMITTER: Huang Y 

PROVIDER: S-EPMC6086364 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature