Regional Adipose Distribution and its Relationship to Exercise Intolerance in Older Obese Patients Who Have Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Objectives

This study sought to test the hypothesis that older obese patients with heart failure with preserved ejection fraction (HFpEF) have significantly greater abdominal, cardiac, and intermuscular fat than healthy, age-matched controls, out of proportion to total body fat, and that these abnormalities are associated with objective measurements of physical function.

Background

Recent studies indicate that excess total body adipose tissue contributes to exercise intolerance in patients with HFpEF. However, the impact of the pattern of regional (abdominal, cardiac, intermuscular) adipose deposition on exercise intolerance in patients with HFpEF is unknown.

Methods

We measured total body adiposity (using dual-energy x-ray absorptiometry) and regional adiposity (usin

SUBMITTER: Haykowsky MJ 

PROVIDER: S-EPMC6086374 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature