The role of TERT promoter mutations in postoperative and preoperative diagnosis and prognosis in thyroid cancer.

ABSTRACT:

Background

Telomerase reverse transcriptase (TERT) promoter mutations have been described in different pathological types of thyroid cancers (TC). After many types of research focusing on the mutations rate in malignant tumors, the main role of TERT promoter mutations has been changed to the preoperative diagnosis and prognosis of TC, according to their high prevalence in aggressive TC.

Methods

We searched Pubmed, Web of Science, Scopus, and VHL and reviewed the most common 2 mutations C288T and C250T in different types of TC, the association between them and some specific clinicopathological features, and their significance in preoperative diagnosis and prognosis of TC. we chose 38 studies into our qualitative research. We also chose 22 studies to do a meta-analysis on this

SUBMITTER: Jin A 

PROVIDER: S-EPMC6086515 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature