ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism.

ABSTRACT: The role of post-transcriptional gene regulation in human brain development and neurodevelopmental disorders remains mostly uncharacterized. ELAV-like RNA-binding proteins (RNAbps) are a family of proteins that regulate several aspects of neuronal function including neuronal excitability and synaptic transmission, both critical to the normal function of the brain in cognition and behavior. Here, we identify the downstream neuronal transcriptional and splicing networks of ELAVL2, an RNAbp with previously unknown function in the brain. Expression of ELAVL2 was reduced in human neurons and RNA-sequencing was utilized to identify networks of differentially expressed and alternatively spliced genes resulting from haploinsufficient levels of ELAVL2. These networks contain a number of autism-rele

SUBMITTER: Berto S 

PROVIDER: S-EPMC6086562 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature