Competing endogenous RNA analysis reveals the regulatory potency of circRNA_036186 in HNSCC.

ABSTRACT: This study aimed to characterize circular RNA (circRNA) expression profiles and biological functions in head and neck squamous cell carcinoma (HNSCC). Differentially expressed circRNAs were screened using an Arraystar Human CircRNA Array and verified by reverse transcription-quantitative polymerase chain reaction. Multiple bioinformatics methods and a hypergeometric test were employed to predict the interactions between RNAs and the functional circRNA‑microRNA (miRNA)-mRNA axes in HNSCC. As a result, 287 circRNAs and 1,053 mRNAs were determined to be differentially expressed in HNSCC compared with the adjacent tissue. In addition, the expression levels of circRNA_036186 and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, ζ polypeptide (14‑3‑3ζ) were identified to be

SUBMITTER: Wang WL 

PROVIDER: S-EPMC6086620 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature