A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans.

ABSTRACT: During awake consciousness, the brain intrinsically maintains a dynamical state in which it can coordinate complex responses to sensory input. How the brain reaches this state spontaneously is not known. General anesthesia provides a unique opportunity to examine how the human brain recovers its functional capabilities after profound unconsciousness. We used intracranial electrocorticography and scalp EEG in humans to track neural dynamics during emergence from propofol general anesthesia. We identify a distinct transient brain state that occurs immediately prior to recovery of behavioral responsiveness. This state is characterized by large, spatially distributed, slow sensory-evoked potentials that resemble the K-complexes that are hallmarks of stage two sleep. However, the ongoing sponta

SUBMITTER: Lewis LD 

PROVIDER: S-EPMC6086660 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature