Alteration of HDL Protein Composition with Hemodialysis Initiation.

ABSTRACT:

Background and objectives

HDL particles obtained from patients on chronic hemodialysis exhibit lower cholesterol efflux capacity and are enriched in inflammatory proteins compared with those in healthy individuals. Observed alterations in HDL proteins could be due to effects of CKD, but also may be influenced by the hemodialysis procedure, which stimulates proinflammatory and prothrombotic pathways.

Design, setting, participants, & measurements

We compared HDL-associated proteins in 143 participants who initiated hemodialysis within the previous year with those of 110 participants with advanced CKD from the Hemodialysis Fistula Maturation Study. We quantified concentrations of 38 HDL-associated proteins relative to total HDL protein using targeted mass spectrometry assays th

SUBMITTER: Wang K 

PROVIDER: S-EPMC6086713 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature