Resilience and White Matter Integrity in Geriatric Depression.

ABSTRACT: OBJECTIVE:Greater psychological resilience may protect against developing depression in a growing geriatric population. Identifying the neural correlates of resilience in geriatric depression could provide neurobiologic targets to inform clinical interventions. However, most prior neuroimaging studies have only considered the presence or absence of resilience and have not addressed the multifactorial nature of resilience. The current study aimed to establish the neural correlates of four factors of resilience in the depressed elderly. METHODS:White matter integrity was assessed using diffusion-weighted magnetic resonance imaging data collected from 70 older adults with major depressive disorder. We used four resilience factors previously derived in an exploratory factor analysis of the Con

SUBMITTER: Vlasova RM 

PROVIDER: S-EPMC6086733 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature