Odorant Item Specific Olfactory Identification Deficit May Differentiate Alzheimer Disease From Aging.

ABSTRACT:

Objectives

To explore whether the ability to recognize specific odorant items is differentially affected in aging versus Alzheimer disease (AD); to refine olfactory identification deficit (OID) as a biomarker of prodromal and early AD.

Design

Prospective multicenter cross-sectional study with a longitudinal arm.

Setting

Outpatient memory diagnostic clinics in New York and Texas.

Participants

Adults aged 65 and older with amnestic mild cognitive impairment (aMCI) and AD and healthy aging (HA) subjects in the comparison group.

Measurements

Participants completed the University of Pennsylvania Smell Identification Test (UPSIT) and neuropsychological testing. AD-associated odorants (AD-10) were selected based on a model of ordinal logistic regression. Age-as

SUBMITTER: Woodward MR 

PROVIDER: S-EPMC6086738 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature