Intranasal oxytocin modulates neural functional connectivity during human social interaction.

ABSTRACT: Oxytocin (OT) modulates social behavior in primates and many other vertebrate species. Studies in non-primate animals have demonstrated that, in addition to influencing activity within individual brain areas, OT influences functional connectivity across networks of areas involved in social behavior. Previously, we used fMRI to image brain function in human subjects during a dyadic social interaction task following administration of either intranasal oxytocin (INOT) or placebo, and analyzed the data with a standard general linear model. Here, we conduct an extensive re-analysis of these data to explore how OT modulates functional connectivity across a neural network that animal studies implicate in social behavior. OT induced widespread increases in functional connectivity in response to po

SUBMITTER: Rilling JK 

PROVIDER: S-EPMC6086772 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature