Genome-wide screening differential long non-coding RNAs expression profiles discloses its roles involved in OHSS development.

ABSTRACT:

Objective

To screen differentially expressed lncRNAs involved in OHSS. OHSS is defined as ovarian hyperstimulation syndrome. It is characterized as enlarged ovary and increased vascular permeability.

Design

Case-control study.

Setting

University-affiliated hospital.

Patient(s)

Patients with OHSS high risk (n = 30) and low risk (n = 30) were included in this study.

Intervention(s)

None.

Main outcome measure(s)

LncRNAs from women with OHSS high risk and low risk were used for high-throughput sequencing profiling. The eight most differentially expressed lncRNAs in granulosa cells were validated by semi-quantitative reverse transcription-polymerase chain reaction analysis.

Result(s)

A total of 23,815 lncRNAs were detected and 482 were different

SUBMITTER: Lin H 

PROVIDER: S-EPMC6086797 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature