Comparative transcriptomic profiling of peripheral efferent and afferent nerve fibres at different developmental stages in mice.

ABSTRACT: Peripheral nerve injury impairs motor and sensory function in humans, and its functional recovery largely depends on the axonal outgrowth required for the accurate reinnervation of appropriate targets. To better understand how motor and sensory nerve fibres select their terminal pathways, an unbiased cDNA microarray analysis was conducted to examine differential gene expression patterns in peripheral efferent and afferent fibres at different developmental stages in mice. Gene ontology (GO) and Kyoto Enrichment of Genes and Genomes (KEGG) analyses revealed common and distinct features of enrichment for differentially expressed genes during motor and sensory nerve fibre development. Ingenuity Pathway Analysis (IPA) further indicated that the key differentially expressed genes were associated

SUBMITTER: Wang H 

PROVIDER: S-EPMC6086926 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature