Arrhythmic hazard map for a 3D whole-ventricle model under multiple ion channel block.

ABSTRACT:

Background and purpose

To date, proposed in silico models for preclinical cardiac safety testing are limited in their predictability and usability. We previously reported a multi-scale heart simulation that accurately predicts arrhythmogenic risk for benchmark drugs.

Experimental approach

We created a comprehensive hazard map of drug-induced arrhythmia based on the electrocardiogram (ECG) waveforms simulated under wide range of drug effects using the multi-scale heart simulator described here, implemented with cell models of human cardiac electrophysiology.

Key results

A total of 9075 electrocardiograms constitute the five-dimensional hazard map, with coordinates representing the extent of the block of each of the five ionic currents (rapid delayed rectifier potassium

SUBMITTER: Okada JI 

PROVIDER: S-EPMC6086978 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature