Eyes absent homologue 2 predicts a favorable prognosis in colorectal cancer.

ABSTRACT:

Purpose

Eyes absent homologue 2 (EYA2), which functions as a transcription activator and phosphatase, plays an important role in several types of cancer. However, the impact of EYA2 in colorectal cancer (CRC) remains elusive.

Patients and methods

We evaluated the significance of EYA2 expression in the development and progression of CRC in a large cohort, including 922 CRC cases. EYA2 protein expression was determined via immunohistochemistry in colorectal tissues. The correlation between EYA2 expression and CRC occurrence was investigated in tumor tissue and the adjacent normal tissues. Factors contributing to CRC prognosis were evaluated using Kaplan-Meier and Cox model analyses.

Results

EYA2 expression was progressively lower in the adjacent normal tissue, adenomas,

SUBMITTER: Zheng J 

PROVIDER: S-EPMC6087027 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature