Indole and 2,4-Thiazolidinedione conjugates as potential anticancer modulators.

ABSTRACT:

Background

Thiazolidinediones (TZDs), also called glitazones, are five-membered carbon ring molecules commonly used for the management of insulin resistance and type 2 diabetes. Recently, many prospective studies have also documented the impact of these compounds as anti-proliferative agents, though several negative side effects such as hepatotoxicity, water retention and cardiac issues have been reported. In this work, we synthesized twenty-six new TZD analogues where the thiazolidinone moiety is directly connected to an N-heterocyclic ring in order to lower their toxic effects.

Methods

By adopting a widely applicable synthetic method, twenty-six TZD derivatives were synthesized and tested for their antiproliferative activity in MTT and Wound healing assays with PC3 (prosta

SUBMITTER: Corigliano DM 

PROVIDER: S-EPMC6087425 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature