Ontology highlight
ABSTRACT:
SUBMITTER: Vlachostergios PJ
PROVIDER: S-EPMC6087439 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Vlachostergios Panagiotis J PJ Jakubowski Christopher D CD Niaz Muhammad J MJ Lee Aileen A Thomas Charlene C Hackett Amy L AL Patel Priyanka P Rashid Naureen N Tagawa Scott T ST
Bladder cancer (Amsterdam, Netherlands) 20180730 3
Urothelial carcinoma (UC) is characterized by expression of a plethora of cell surface antigens, thus offering opportunities for specific therapeutic targeting with use of antibody-drug conjugates (ADCs). ADCs are structured from two major constituents, a monoclonal antibody (mAb) against a specific target and a cytotoxic drug connected via a linker molecule. Several ADCs are developed against different UC surface markers, but the ones at most advanced stages of development include sacituzumab g ...[more]