Radiation Therapy as Definitive Local Treatment in Patients with Limited-Stage Small Cell Carcinoma of the Bladder: Does total dose matter?

ABSTRACT:

Purpose

To determine whether total radiation dose affects survival outcomes for patients with small cell carcinoma of the bladder (SCCB).

Methods

We queried the National Cancer Database (NCDB) for patients with limited stage SCCB undergoing multimodality treatment and retrospectively analyzed survival outcomes according to total radiation dose received.

Results

Patients aged 41-79 receiving a total radiation dose of 54 Gy or greater had a significant improvement in overall survival compared to those receiving less than 54 Gy, with a median overall survival of 58.9 months (95% confidence interval [CI] 37.2-80.6 months) compared to 21.5 months (95% CI 15.2 -27.8 months) (p < 0.05). There was no difference in outcomes for patients receiving between 54 and 60 Gy co

SUBMITTER: Germino E 

PROVIDER: S-EPMC6087459 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature