Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome.

ABSTRACT:

Importance

Colorectal carcinomas in patients with Lynch syndrome (LS) arise in a background of mismatch repair (MMR) deficiency, display a unique immune profile with upregulation of immune checkpoints, and response to immunotherapy. However, there is still a gap in understanding the pathogenesis of MMR-deficient colorectal premalignant lesions, which is essential for the development of novel preventive strategies for LS.

Objective

To characterize the immune profile of premalignant lesions from a cohort of patients with LS.

Design, setting, and participants

Whole-genome transcriptomic analysis using next-generation sequencing was performed in colorectal polyps and carcinomas of patients with LS. As comparator and model of MMR-proficient colorectal carcinogenesis, we us

SUBMITTER: Chang K 

PROVIDER: S-EPMC6087485 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature