Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.

ABSTRACT: Disease-free infection in HIV-infected adults is associated with human leukocyte antigen-mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural hosts of simian immunodeficiency virus (SIV), viral replication continues unabated. To better understand factors preventing HIV disease, we investigated pediatric infection, where AIDS typically develops more rapidly than in adults. Among 170 nonprogressing antiretroviral therapy-naïve children aged >5 years maintaining normal-for-age CD4 T cell counts, immune activation levels were low despite high viremia (median, 26,000 copies/ml). Potent, broadly neutralizing antibody responses in most of the subjects and strong virus-specific T cell activity were present but did not drive pediatric nonprogression. However, red

SUBMITTER: Muenchhoff M 

PROVIDER: S-EPMC6087524 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature