Determination of a Predictive Cleavage Motif for Eluted Major Histocompatibility Complex Class II Ligands.

ABSTRACT: CD4⁺ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway. Identification of epitopes is important and computational prediction of epitopes is used widely to save time and resources. Although there are algorithms to predict binding affinity of peptides to MHC II molecules, no accurate methods exist to predict which ligands are generated as a result of natural antigen processing. We utilized a dataset of around 14,000 naturally processed ligands identified by mass spectrometry of peptides eluted from MHC class II expressing cells to investigate the existence of sequence signatures potentially related to the cleavage mechan

SUBMITTER: Paul S 

PROVIDER: S-EPMC6087742 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature